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Cysteine anabolism and its interplay with other metabolic pathways in cancer De novo cysteine synthesis The de novo synthesis of cysteine occurs through the trans-sulphuration pathway of the methionine cycle, which also involves serine (Fig

A primary mechanism is the disruption of the epithelial barrier via its virulence adhesin FadA, which binds to E-cadherin on host cells, leading to the activation of the NF-B pathway and the upregulation of pro-inflammatory cytokines such as TNF-, IL-1, and IL-6 (Li et al., 2021

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doi: 10.3389/fpubh.2024.1277113